Measurement and translation techniques of bio-information from human body by electromagnetic field approach are developed. We develop minimally invasive medical devices and welfare equipment by using electromagnetic phenomena.
Tracking a nasogastric tube inside a rabbit
Measurement of Magneto Cardiogram without magnetic shielding
Ultrasound, whose information has been widely used for medical diagnosis, is now becoming to be used for therapy by focusing its energy into a tumor. Not only the technology to focus ultrasonic energy into non-superficial tissue to be treated but also the imaging technologies to aim the tissue and to detect its change due to treatment in real time are required. Furthermore, a tissue selective ultrasonic sensitizer, which induces therapeutic effect at lower ultrasonic intensity, can markedly improve the safety and efficiency of the ultrasonic treatment.
Tissue heating enhancement with microbubbles
Students during experiments
Most cancer cells are invasive and metastatic, and they become disseminated to distant anatomical sites by invasive-metastasis cascade. We will develop diagnosis and treatment methods of lymph node metastasis at the early stages. Our research is interdisciplinary or integrated research based on fluid dynamics, optics, molecular cell biology, oncology, and pathology. Our research subjects are as follows.
Development of early diagnostic and treatment for lymph node metastasis requires an animal model applicable to clinical trial. We have succeeded in developing the first lymph node metastasis model in which tumour cells introduced into the lymphatic circulation by direct injection into the inguinal lymph nodes induce metastasis in the axillary lymph nodes. (A) lymph node metastasis, (B) metastasis site, (C) angiogenesis captured by high-frequency ultrasound and nanobubbles
The aim of our researches is to contribute to the creation of highly advanced medical technology using high technology in bio-dental engineering. In our research, we will develop wireless motion capture system for human body and create reformative functional biomaterials using Ni-free Ti-based shape memory alloys or biodegradable materials. We aim to clinical applications of these new technologies though multifaceted assessments for clinical usefulness.
Development of deglutition evaluation system using magnetic wireless motion capture system.
New internalized orthopedic device for craniofacial plastic surgery using Ni-free Ti-based shape memory alloy.
Improvements of biofunctionalized reconstruction systems are expected in our country, which has entered the period of a “super-aging society.” Our objective is to make enhancements to hard-tissue substitution systems such as artificial hip joints and dental implants. We focus on metallic biomaterials such as titanium and Co-Cr-Mo alloys and ceramics such as calcium phosphate. We conduct a fundamental study on the process of manufacturing these materials and the control of surface and interfacial reactions under in vitro conditions on the basis of the physical chemistry. Furthermore, we carry out an application study on the development of surface modification processes and suitable materials for use in the fabrication of artificial hip joints showing improved biocompatibility with bones.
Cross section of amorphous calcium phosphate (ACP) coating film fabricated by RF magnetron sputtering (a) before and (b) after 1 week implantation.
Relationship between ISQ and removal torque of ACP-coated and uncoated implants from the femur, 1, 2, and 4 weeks after implantation.
Biofunctional materials process by understanding biofunctions at a biomolecular environmental level plays a pivotal role in designing biofunctional materials for advanced medicine such as regenerative medicine and drug delivery systems. Our objective is to molecularly understand biofunctions to develop novel biofunctional materials as well as to pursue fundamental researches on organic-inorganic hybrids and soft matters being applicable for biological systems. Moreover, we also design biofunctional materials such as polymeric vesicles and hydrogels on the basis of the fundamental findings and study on their applications for regenerative medicine and drug delivery systems.
Development of biofunctional materials process for regenerative medicine and drug delivery systems