Sound information, which is converted to the electrical spike signal of the cochlear nerve in the inner ear, is transmitted to the brain via the auditory system. Disturbance of any part of auditory system causes hearing impairment. In considering the improvement of speech perceptibility of impaired listeners, it is important to understand the pathology and pathophysiology of deafness. In our laboratory, researches being conducted on auditory prostheses and related auditory science to help impaired listeners compensate for the deteriorated speech perception.
Electrophysiological mapping system for auditory brainstem implant
Neuromagnetic investigation on auditory steady state response
The central nervous system (CNS) is especially vulnerable and has limited potential for regeneration in the baseline level. Even with the current sophisticated treatments for CNS injury, lots of patients get disabled. We reveal pathophysiology of CNS diseases with both biological and engineering approaches and develop new treatments for CNS injuries.
Experimentally induced aneurysm in rat. The process related to the initiation, growth, rupture and cure is analyzed. This model is useful to study new development of endovascular devices and and pharmacological therapy.
Patient data specific CFD analysis of brain aneurysm. This type of aneurysm had strong relationship between maximum wall shear stress and growth and rupture.
We try to understand mucosal defense system, mechanism of food transport and reservation, process of nutrients digestion and absorption, and symbiosis of enteric flora and the host. We investigate compensatory mechanisms of the body after massive resection of the gastrointestinal tract qualitatively and quantitatively using various methodologies such as histology, immunohistochemistry, molecular biology, and electrophysiology. We aim to develop novel research systems and therapies to improve GI dysfunction and to enhance quality of life by applying new concept, materials, and methods.
Aldosterone-incorporated D,L-lactide/glycolide copolymer microspheres: aldosterone release in the ileal mucosa and induction of electrogenic sodium absorption
To develop newly bone regenerative materials and to apply them for clinical use, we intend to regenerate loss of living hard tissue such as bone that was lost by various diseases. To accomplish the goals, we aim to elucidate the mechanism of bone regeneration through establishment of animal models for bone regeneration and various techniques including a characteristic ones on hard tissue, and through analysis of biological responses for various bone regenerative materials by experiments with animals.
Clinical trial of octacalcium phosphate collagen composites (OCP/Col)
Bone regeneration by OCP/Col in large animals
Variety of membrane transport systems play essential roles for maintaining homeostasis in the body. In addtion, many membrane transporters involve in the regulation pathogenesis of renal failure, hypertension and cancer as well as diabetes and obesity. We sudy for developing diagnositc tools or screeing new drug by modulating such molecules.
Renal-specific gene delivery