Students in the Course of Regenerative and Biomedical Engineering learn to apply engineering techniques to regeneration from the standpoints of both form and function. Starting from regeneration at the cell and tissue level, they study the restoration of functions by means of artificial organs, and go on to the more complex challenge of developing and establishing information engineering technologies for controlling life functions. We teach the following fields.
Rehabilitative Auditory Science
Hearing restoration for deafened patients using the approach based on the biomedical engineering
Sound information, which is converted to the electrical spike signal of the cochlear nerve in the inner ear, is transmitted to the brain via the auditory system. Disturbance of any part of auditory system causes hearing impairment. In considering the improvement of speech perceptibility of impaired listeners, it is important to understand the pathology and pathophysiology of deafness. In our laboratory, researches being conducted on auditory prostheses and related auditory science to help impaired listeners compensate for the deteriorated speech perception.
- Development of diagnostic tools based on the pathophysiology of hearing loss
- Research on auditory prosthesis (cochlear, brainstem and mid-brain implants, hearing aid)
- Research on auditory rehabilitation
- Research on binaural hearing and audio-visual bimodal speech perception
Electrophysiological mapping system for auditory brainstem implant
Neuromagnetic investigation on auditory steady state response
Department of Neurosurgical Engineering and Translational Neuroscience
Development of new tools and therapies for neurosurgical diseases, and rapid translation to patientse
The central nervous system (CNS) is especially vulnerable and has limited potential for regeneration in the baseline level. Even with the current sophisticated treatments for CNS injury, lots of patients get disabled. We reveal pathophysiology of CNS diseases with both biological and engineering approaches and develop new treatments for CNS injuries.
- Development of neuro-regenerative therapy with multi-lineage differentiating stress enduring (Muse) cells.
- Development of new thrombolytic and neuroprotective agents.
- Development of materials for bone regeneration.
- Research for hemodynamics of cerebral aneurysms using computational fluid dynamics (CFD)
- Research for molecular pathways of CNS injuries.
Experimentally induced aneurysm in rat. The process related to the initiation, growth, rupture and cure is analyzed. This model is useful to study new development of endovascular devices and and pharmacological therapy.
Patient data specific CFD analysis of brain aneurysm. This type of aneurysm had strong relationship between maximum wall shear stress and growth and rupture.
Gastrointestinal Tract Reconstruction
Development of novel technology which compensates for impaired gastrointestinal function
We try to understand mucosal defense system, mechanism of food transport and reservation, process of nutrients digestion and absorption, and symbiosis of enteric flora and the host. We investigate compensatory mechanisms of the body after massive resection of the gastrointestinal tract qualitatively and quantitatively using various methodologies such as histology, immunohistochemistry, molecular biology, and electrophysiology. We aim to develop novel research systems and therapies to improve GI dysfunction and to enhance quality of life by applying new concept, materials, and methods.
- Investigation of compensatory mechanisms after massive bowel resection and development of novel therapies for impaired GI function due to removal of the GI tract
- Three dimensional construction of artificial intestinal mucosa and development of an artificial intestine
- Development of new surgical devices
- Application of beneficial intestinal flora for prevention and therapies of GI diseases
Aldosterone-incorporated D,L-lactide/glycolide copolymer microspheres: aldosterone release in the ileal mucosa and induction of electrogenic sodium absorption
Bone Regenerative Engieering
Development and in vivo evaluation of new bone regenerative materials toward clinical application
To develop newly bone regenerative materials and to apply them for clinical use, we intend to regenerate loss of living hard tissue such as bone that was lost by various diseases. To accomplish the goals, we aim to elucidate the mechanism of bone regeneration through establishment of animal models for bone regeneration and various techniques including a characteristic ones on hard tissue, and through analysis of biological responses for various bone regenerative materials by experiments with animals.
- Bone regeneration by octacalcium collagen composite
- Establishment of a new animal model for bone regeneration
- Research for quantification of regenerated bone tissue
Clinical trial of octacalcium phosphate collagen composites (OCP/Col)
Bone regeneration by OCP/Col in large animals
Development of remedies for cancer, hypertension, diabetes and renal failure
Variety of membrane transport systems play essential roles for maintaining homeostasis in the body. In addtion, many membrane transporters involve in the regulation pathogenesis of renal failure, hypertension and cancer as well as diabetes and obesity. We sudy for developing diagnositc tools or screeing new drug by modulating such molecules.
- Characterization of membrane transport systems
- Search of diagnostic tool and new drugs for renal failure and hypertension
- Discovery of anti-cancer drugs
- Research for diabetes and obesity
Renal-specific gene delivery